{"id":15181,"date":"2017-01-09T01:00:32","date_gmt":"2017-01-09T06:00:32","guid":{"rendered":"https:\/\/cna.ca\/fr\/?post_type=news&p=15181"},"modified":"2020-03-10T13:55:02","modified_gmt":"2020-03-10T17:55:02","slug":"whats-in-your-blood-3","status":"publish","type":"post","link":"https:\/\/cna.ca\/fr\/2017\/01\/09\/whats-in-your-blood-3\/","title":{"rendered":"Radioimmunoessai : pour savoir ce qui circule dans votre sang"},"content":{"rendered":"

Il s’agit d’une technique de m\u00e9decine nucl\u00e9aire dont vous n’avez peut-\u00eatre jamais entendu parler. Le radioimmunoessai ou RIA est un examen diagnostic qui s’effectue dans un laboratoire d’h\u00f4pital et qui permet de mesurer la pr\u00e9sence de biomat\u00e9riaux dans votre corps, dans le cadre d’un processus impliquant l’utilisation de radio-isotopes.<\/p>\n

Selon Jenny Ryan, sp\u00e9cialiste en communication scientifique pour le compte de la Soci\u00e9t\u00e9 canadienne du sang (SCS), \u00ab\u00a0le RIA permet de d\u00e9terminer la chimique particuli\u00e8re de diverses substances circulantes. Ce type d’examen est d’un usage fr\u00e9quent dans le domaine de la chimie des st\u00e9ro\u00efdes (p.\u00a0ex. hormones de fertilit\u00e9, vitamines, st\u00e9ro\u00efdes, ainsi que certains diagnostics du cancer)\u00a0\u00bb.<\/p>\n

\"copyright-jarun-ontakrai\"

Copyright: Jarun Ontakrai<\/p><\/div>\n

Le RIA permet d’analyser de grosses mol\u00e9cules complexes qu’il serait difficile d’examiner autrement. Il est possible de doser des virus, des ulc\u00e8res gastriques, des globules (leuc\u00e9mie), et m\u00eame de l’insuline \u00e0 l’aide d’un RIA.<\/p>\n

Cet examen a \u00e9t\u00e9 mis au point \u00e0 la fin des ann\u00e9es\u00a050 par les scientifiques Rosalyn Yalow et Solomon Berson<\/a>. Leur d\u00e9couverte, qui montre ce que qui se passe dans le corps humain, a valu \u00e0 Rosalyn Yalow le prix Nobel de physiologie et m\u00e9decine en 1977.<\/p>\n

Le RIA n\u00e9cessite l’utilisation d’un radio-isotope, d’anticorps (\u00e9galement connus sous le nom d’immunoglobulines) et d’un \u00e9chantillon de sang du patient. Une fois l’hormone dos\u00e9e, on marque celle-ci \u00e0 l’aide d’un radio-isotope. On m\u00e9lange ensuite la solution et les anticorps, aussi appel\u00e9s \u00ab\u00a0prot\u00e9ines\u00a0\u00bb. Le radio-isotope et les anticorps se combinent chimiquement.<\/p>\n

La prochaine \u00e9tape consiste \u00e0 ajouter le sang du patient \u00e0 ce m\u00e9lange. Cet \u00e9chantillon de sang contient une certaine quantit\u00e9 de l’hormone qui est dos\u00e9e. Au fur et \u00e0 mesure que le sang est inject\u00e9, les anticorps s’\u00e9loignent des radio-isotopes et s’apparient avec les hormones naturelles s\u00e9cr\u00e9t\u00e9es. Une fois que tous les anticorps se sont \u00e9loign\u00e9s et se sont appari\u00e9s avec les hormones contenues dans le sang, les chercheurs d\u00e9sapparient hormones et anticorps (les radioactifs comme les non radioactifs), puis ils mesurent la radioactivit\u00e9 du m\u00e9lange.<\/a><\/strong><\/em><\/p>\n

L’\u00e9cart de radioactivit\u00e9 du m\u00e9lange se nomme \u00ab\u00a0dosage\u00a0\u00bb ou \u00ab\u00a0dose\u00a0\u00bb, et il r\u00e9v\u00e8le le taux d’hormones naturelles que contient le sang.<\/p>\n

Par exemple, s’il s’agit d’un dosage d’insuline, on m\u00e9lange l’insuline marqu\u00e9e d’un radio-isotope avec les anticorps. Ensuite, on ajoute l’\u00e9chantillon de sang du patient. L’insuline contenue dans le sang<\/a> remplace une partie de l’insuline marqu\u00e9e. On mesure alors l’insuline \u00e9pur\u00e9e \u00e0 l’aide d’un d\u00e9tecteur de radio-isotopes, puis on calcule le taux d’insuline du patient.<\/strong><\/em><\/p>\n

Le radioimmunoessai constitue une \u00e9tape importante pour l’\u00e9tablissement d’un diagnostic pr\u00e9cis et pr\u00e9coce, notamment pour le cancer du c\u00f4lon. Le cancer colorectal<\/a> figure au deuxi\u00e8me rang des cancers les plus r\u00e9pandus. Chaque ann\u00e9e, il touche pr\u00e8s de 30\u00a0000\u00a0Canadiens et pr\u00e8s d’un million de cas sont diagnostiqu\u00e9s dans le monde. Un d\u00e9pistage pr\u00e9coce peut jouer un r\u00f4le cl\u00e9 en mati\u00e8re de survie.<\/p>\n

Le radioimmunoessai, c’est la fili\u00e8re nucl\u00e9aire pour le diagnostic de maladies.<\/p>\n","protected":false},"excerpt":{"rendered":"

Il s’agit d’une technique de m\u00e9decine nucl\u00e9aire dont vous n’avez peut-\u00eatre jamais entendu parler. Le radioimmunoessai ou RIA est un examen diagnostic qui s’effectue dans un laboratoire d’h\u00f4pital et qui permet de mesurer la pr\u00e9sence de biomat\u00e9riaux dans votre corps, dans le cadre d’un processus impliquant l’utilisation de radio-isotopes. Selon Jenny Ryan, sp\u00e9cialiste en communication […]<\/p>\n","protected":false},"author":1,"featured_media":15872,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[244],"tags":[],"topic":[],"class_list":["post-15181","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-contenu-vedette"],"acf":[],"yoast_head":"\nRadioimmunoessai : pour savoir ce qui circule dans votre sang - Association nucl\u00e9aire canadienne<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cna.ca\/fr\/2017\/01\/09\/whats-in-your-blood-3\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Radioimmunoessai : pour savoir ce qui circule dans votre sang - Association nucl\u00e9aire canadienne\" \/>\n<meta property=\"og:description\" content=\"Il s’agit d’une technique de m\u00e9decine nucl\u00e9aire dont vous n’avez peut-\u00eatre jamais entendu parler. 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